Click Chemistry

The term ‘click chemistry’ describes a class of efficient and selective reactions capable to combine building blocks in a rapid fashion and at high yields.

Several of our most sensitive Seta Dyes are now available as azides to be reacted with C-C-triple bonds in either a Cu(I)-catalized or Cu-free 1,3-dipolar cycloaddition reaction to a triazole (see figure). Both reactions proceed in aqueous environments with adequate efficiency.

We also offer reagents for strain-mediated cyclization reactions without the need for a Cu-catalyst using cyclo-octynes. Initially, the copper(I)-catalyzed azide-alkyne cycloaddition was the only click reaction. The metal-free reactions have a wider applicability and are compatible for cell-based applications.